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The source of three postbiotic active ingredients

AQUAPHILUS DOLOMIAE The source of three postbiotic active ingredients

After more than 12 years of work, Pierre Fabre Research researchers discovered that there was a Thermal Spring Water other than mineral water. They unlocked the secrets of a unique and as yet unknown microorganism.

A microflora linked to the exceptional purity of the surrounding environment which they named Aquaphilus Dolomiae. This bacteria, which exists in no other ecosystem in the world, is at the source of active substances contributing, partly, to the effectiveness of Avène Thermal Spring Water.

I-modulia®, the first anti-itching postbiotic active ingredient

Avène Thermal Spring Water is known for its soothing and anti-irritant effect on the skin, partly explained by its unique biological signature: Aquaphilus Dolomiae. This microflora, isolated and then amplified by biotechnology, is the source of the first anti-irritant postbiotic active ingredient: I-modulia®

It calms itching, soothes atopic dermatitis and has measurable effects on eczema. It is at the centre of the XeraCalm A.D. range. A skincare line designed precisely to relieve itching and make it disappear after 5 days.

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[C+-Restore]™ the repairing agent for sensitive skin

The healing properties of Avène Thermal Spring Water have been scientifically proven and demonstrated in the laboratory. While trying to understand this repairing mechanism, researchers isolated and patented [C+-Restore]™ from the Avène Thermal Spring Water microbiota. A new generation, unique postbiotic active ingredient that promotes epidermal repair and is at the heart of the Cicalfate+ range.

When combined with a Copper/Zinc anti-bacterial complex and, soothing and anti-irritant, Avène Thermal Spring Water, it helps repair irritated sensitive skin for up to 48 hours.

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We work in the opposite direction to that used to create medicines, by starting with a molecule to test its activity. It is a fascinating, in-depth analysis.

D-Sensinose™, an innovation to control skin hyper-reactivity

Avène Thermal Spring Water has soothing and anti-irritant properties thanks to its unique mineral and biological double signature. Our researchers have developed a unique and patented postbiotic active ingredient from this water: D-Sensinose™. It regulates all skin hypersensitivity and shows off all its powers in our Tolérance CONTROL skincare range. It immediately calms hypersensitive skin and durably controls reactivity. The skin is soothed in 30 seconds, and its protective barrier is restored in 48 hours.


This third postbiotic active ingredient is the one that concentrates all the inner richness of Aquaphilus Dolomiae.

Katia Ravard-HelfferEau Thermale Avène Innovation Project Manager
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