Cleanance Comedomed has not been marketed since 2/3/2025 . You can see all product information below.

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CLEANANCE COMEDOMED Anti-blemishes Concentrate.

Cleanance Comedomed anti-blemishes concentrate reduces the appearance of spots and blackheads and limits their recurrence*. Prescribed by dermatologists**.

Cleanance

Cleanance Comedomed

Fast-acting, prevents recurrence***, high tolerance

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Cleanance

Cleanance Comedomed

Permanent

Tightens pores - Reduces excess sebum - Reduces imperfections

Cleanance Comedomed, an innovation from Laboratoires Eau Thermale Avène, fights spots and prevents them reappearing, with clinically proven effectiveness from seven days*. High tolerance for acne-prone skin.

Action rapide
Anti-récidive***
Haute tolérance
Sans parfum

Effectiveness demonstrated within 7 days*.
Fast-acting, prevents recurrence***, high tolerance

Usable by

Pregnant women - Young mothers - Teenagers - Adults

Age

From 12 year(s)

Suitable

Chest - face - back

Skin type

Acne-prone skin

Need

Anti-imperfections - Anti recurrence

Made in France

Cleanance Comedomed, an innovation from Laboratoires Eau Thermale Avène has shown proven clinical effectiveness from seven days*, fights spots from the root with a unique action, and prevents them reappearing. Expert care for oily, acne-prone skin, Cleanance Comedomed is formulated using Comedoclastin™, a plant extract from the seeds of milk thistle. This active ingredient with patented properties** directly targets micro blackheads, reduces existing spots and blackheads and prevents new ones appearing. Cleanance Comedomed, applied twice a day, reduces spots within seven days* and provides clinically proven*** anti-recurrence action. Can be used by adults and teenagers from the age of 12. Non-comedogenic, high-tolerance* for acne-prone skin, its fast-absorbing, non-greasy texture leaves skin mattified. Cleanance Comedomed can be used alone, with other products, or after acne medication (excluding oral isotretinoin).

Benefit

The revolutionary treatment for acne-prone skin that reduces spots within seven days* and limits their reappearance thanks to Comedoclastin™, a plant-based active ingredient extracted from Milk Thistle, with patented properties**

Benefits

• EFFECTIVENESS that is clinically proven. Reduces all types of acne-prone skin imperfections, thanks to Comedoclastin™** which acts at the root of spots to reduce them and limit them reappearing. Its light aqueous texture penetrates quickly, making it easier to apply, and leaves the skin supple, moisturised and mattified over time.

• FAST ACTION AND PREVENTS RECURRENCE : Cleanance Comedomed is clinically proven to reduce spots within seven days* and prevent recurrence***. For clearer skin and improved comfort every day.

• HIGH TOLERANCE : Cleanance Comedomed is highly tolerant*, whether used alone, in combination or in tandem with medical treatments (excluding oral isotretinoin). Its non-comedogenic formula is fragrance-free.

Texture benefit

A light, watery texture that is quickly absorbed and has a non-greasy finish that leaves the skin clean and matte.

Product scent

Fragrance-free

Packaging that does not contain recycled material
Fully recyclable packaging

18/4/2025

*Tolerance and efficacy study under dermatological control on 51 subjects, use of Cleanance Comedomed twice a day for 56 days.

*Tolerance and efficacy study under dermatological control on 51 subjects, use of Cleanance Comedomed twice a day for 56 days.

** Patent registered.

***International clinical observational study, 90% of patients without acne relapse at T6 months, (according to the definition of relapse in the GEA protocol ≥3 requiring the introduction of a drug treatment - oral or local), 48 subjects, two applications per day of Cleanance Comedomed for six months.

*Tolerance and efficacy study under dermatological control on 51 subjects, use of Cleanance Comedomed twice a day for 56 days.

** Patent registered.

Environmental impact

Formula

Biodegradable formula*
Formulated to limit the impact on the aquatic environment***
*According to a OECD 301 test or biodegradability index method
*** According to a OECD 301 test and CLP classification of the formula

Packaging

Fully recyclable packaging

Manufacturing

Formulated with one or more raw materials from the circular economy
Manufactured and packaged in an environmentally certified facility****
Cold-made formula without any heating
****According to ISO 14001 and/or 50001

Transportation

Low CO2 impact of raw material transport (< 70 g CO2 eq. )

Societal impact

Product manufactured and packaged in a factory with high social standards
Avene is a brand of the Pierre Fabre Group, certified at the highest Exemplary level of AFNOR Certification’s Committed to CSR and Responsibility Europe labels, thus consolidating a long-standing commitment to contributing to sustainable development.
Does not contain animal raw materials

Our commitments

The Green Impact Index is a tool displaying the environmental and societal impact of cosmetics, dietary supplements and wellness and family health products, based on the methodology of the AFNOR Spec 2215. Developed thanks to the contribution of 22 companies, associations and federations, it assesses your products on more than 50 criteria for ever greater transparency!

Understanding the Green Impact Index

Application

Helping you get rid of blemishes once and for all

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Frequency of use

2 times a day

Tips for use

Dispense 1 dose of Cleanance Comedomed on your fingertips.
• Start by dabbing it onto the T-zone and the cheeks.
• Use circular motions to boost penetration.
• Finish by smoothing on the cheeks and lower face.
Reapply morning and evening.

An expert tip

The 2 essential steps to take care of your oily, acne-prone skin!
Our one piece of advice:
• Rigorously yet gently remove make-up and cleanse the face, both morning and evening!
• Also apply an anti-blemish product morning and evening.

Clinical results

Effective for every oily,acne-prone skin type

7 days
reduces spots within 7 days¹
90%
prevents recurrence for 90%²
45%
reduced imperfections by -45% as of 2 months³, significant result versus control group

¹Tolerance and efficacy study under dermatological control on 51 subjects, use of Cleanance Comedomed twice a day for 56 days.

²International observational clinical study, 90% of patients without acne relapse at T6 months, (according to the definition of relapse in the protocol GEA≥3 requiring the introduction of an oral or local drug treatment), 48 subjects, 2 applications per day of Cleanance Comedomed alone for 6 months.

³36 subjects with slight to moderate imperfections. Comparative clinical study (group treated twice/day N=18), control group (N=18) for 56 days.

Cleanance

Reduce spots, regain control over your skin.

Find out more

Ingredients

A combination of innovative active ingredients selected for their effectiveness on sensitive oily, acne-prone skin.

AVENE THERMAL SPRING WATER (AVENE AQUA). ISOPROPYL ALCOHOL. PEG-6. GLYCERIN. SILYBUM MARIANUM FRUIT EXTRACT. SILICA. POLYACRYLATE-13. POLYISOBUTENE. POLYSORBATE 20. SORBITAN ISOSTEARATE. WATER (AQUA)

The consumer is advised to systematically check the composition of the product before purchasing it.

Comedoclastin™

Plant-based active ingredient with patented properties from Pierre Fabre Research. Milk thistle extract acts on epithelial cells reducing the formation of micro-comedones and preventing new spots.

Avene thermal water

Thanks to a unique mineral and biological characteristic, it has soothing, repairing and rebalancing properties.

FREQUENTLY ASKED QUESTIONS

Any concerns or questions? Our experts are here for you.

Rest assured, Cleanance Comedomed does not contain any.

The smell is linked to the active ingredient Comedoclastin™ (milk thistle extract), which is present in the product at a dosage of 25%. This odour evaporates quickly and does not interfere with the tolerance of the product and does not present any risk to the skin. It has been proven that skin tolerates Cleanance Comedomed extremely well.

Yes, the start of an active treatment (whether a drug or dermo-cosmetic) can act as a trigger for a breakout. Under its effect, a large number of spots, previously dormant under the skin, emerge at the same time. This causes the phenomenon of a "flare-up" (an explosion or exacerbation of pimples). Treatment should be continued in all cases, because the next phase will allow for the rapid exhaustion of the "embryo stock” of spots.This will help to keep blemishes to a minimum.
In case of discomfort, use can be reduced to once a day.